Development of a calculated panel reactive antibody web service with local frequencies for platelet transfusion refractoriness risk stratification
نویسندگان
چکیده
منابع مشابه
Application of Calculated Panel Reactive Antibody Using HLA Frequencies in Koreans
BACKGROUND Introduction of the Luminex panel reactive antibody (PRA)-single antigen (SA) assay has increased the detection rates of unacceptable antigens in sensitized patients; the calculated PRA (CPRA) level represents the percentage of actual organ donors that express 1 or more of these unacceptable antigens. We developed a CPRA calculator based on the HLA frequencies in Koreans to measure s...
متن کاملEvaluation of platelet antigens and antibodies in patients with platelet refractoriness
Abstract Background and Objectives Immune platelet refractoriness is a complication of blood transfusion in patients with multiple platelet transfusions. Antibodies against surface antigens, including human platelet antigens (HPAs) and human leukocyte antigens (HLAs), can be produced which can cause the degradation of transfused platelets by macrophages. In this study, the frequency of platele...
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A variety of patientand product-related factors influenced the outcome of 6379 transfusions given to 533 patients in the Trial to Reduce Alloimmunization to Platelets (TRAP). Responses measured were platelet increments, interval between platelet transfusions, and platelet refractoriness. Patient factors that improved platelet responses were splenectomy and increasing patient age. In contrast, a...
متن کاملEmergency transfusion for acute severe anemia: a calculated risk.
An editorial about a case report is unusual, but no more so than the case reported by Dai et al. in this issue of the journal. They report survival, without apparent sequelae, of a 53-year-old man with a hemoglobin concentration as low as 0.7 g/dL (hematocrit 2.2%) for several hours. Despite the presence of a low fibrinogen concentration and an elevated partial thromboplastin time (not discusse...
متن کاملEfficiency of treatment with rituximab in platelet transfusion refractoriness: a study of 7 cases.
OBJECTIVE The purpose of our study was to evaluate the efficacy and safety of rituximab in treatment of immune PR. METHODS We retrospective analysis 7 paitents (5 aplastic anemia, 2 myelodysplastic syndrome) with immune PR who received at least 3 weekly infusions of rituximab (375 mg/m(2)). RESULTS All enrolled patients acquired improvement of platelets transfusion more than 2 months (CCI ≥...
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ژورنال
عنوان ژورنال: Journal of Pathology Informatics
سال: 2019
ISSN: 2153-3539
DOI: 10.4103/jpi.jpi_29_19